Animal models of NASH: Getting both pathology and metabolic context right

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Animal models of NASH: getting both pathology and metabolic context right.

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease. The main risk factors for NAFLD/NASH are the metabolic abnormalities commonly observed in metabolic syndrome: insulin resistance, visceral obesity, dyslipidemia and altered adipokine pr...

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Animal models suggest that a month of heightened plasticity occurs in the brain after stroke, accompanied by most of the recovery from impairment. This period of peri-infarct and remote plasticity is associated with changes in excitatory/inhibitory balance and the spatial extent and activation of cortical maps and structural remodeling. The best time for experience and training to improve outco...

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Animal Models of Human Pathology

Animal models of human pathologies, including naturally occurring, induced, or engineered animals, are valuable tools for understanding the physiopathology of the disease and discovering novel therapeutic targets and drugs. In fact, although scientific research has always relied on the use of cell cultures, information that is obtained through in vitro studies can be extrapolated to the biomedi...

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In this special issue we gather together 23 articles (15 reviews, 7 research articles, and 1 methodology report) with diverse information presently available on animal models of human disease. The use of animal for studying human diseases, from the pathogenesis to the clinical aspects of diagnosis and therapy, has always been a very useful tool and indeed, has contributed enormously to our unde...

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1 Istituto per l’Endocrinologia e l’Oncologia Sperimentale (IEOS), CNR, 80131 Naples, Italy 2Santiago University Clinical Hospital, Instituto de Investigación Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain 3Human Cancer Genetics Program/CCC, The Ohio State University, Columbus, OH 43210, USA 4Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00100 Ro...

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ژورنال

عنوان ژورنال: Journal of Gastroenterology and Hepatology

سال: 2008

ISSN: 0815-9319,1440-1746

DOI: 10.1111/j.1440-1746.2008.05543.x